Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension

Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension.

Inhaled nitric oxide (NO) causes selective pulmonary vasodilation and improves gas exchange in acute lung failure. In experimental pulmonary hypertension, we compared the influence of the aerosolized vasodilatory prostaglandins (PG) PGI2 and PGE1 on vascular tone and gas exchange to that of infused prostanoids (PGI2, PGE1) and inhaled NO. An increase of pulmonary artery pressure (Ppa) from 8 to...

Vasodilators in pulmonary hypertension.

Inhaled pulmonary vasodilators in refractory hypoxemia

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0/). Patients on invasive mechanical ventilation with persistent hypoxemia despite supplemental oxygen (FiO2) usually have significant shunt physiology and/or low cardiac output. If faced with refractory hypoxemia or acute right vent...

Pregnant patient with primary pulmonary hypertension: inhaled pulmonary vasodilators and epidural anesthesia for cesarean delivery.

Address reprint requests to Dr. Weiss: Department of Anesthesiology, University Hospital, Raemistr 100, CH-8091 Zurich, Switzerland. Address electronic mail to: [email protected] plicated delivery of a neonate. She refused treatment at that time. During her second pregnancy, at 15 weeks’ gestation, Doppler echocardiography showed a right atrial diameter of 6.2 cm (normal diameter, 2.2-4.1...

Inhaled vasodilators as a new treatment strategy in pulmonary hypertension with left heart disease

Patients with congestive heart failure (CHF) develop pulmonary hypertension due to an increase in pulmonary vascular resistance (PVR). These patients may benefit from inhaled vasodilators to selectively reduce PVR. Here, we studied the effects of inhaled vasodilators on pulmonary and systemic hemodynamics and lung edema formation in a rat model of CHF. Since lungs of CHF patients are partially ...